Police are currently responding to a report of a serious collision involving a motorcycle and a lorry on the A63 eastbound at North Cave, Brough.
A number of emergency services are attending and the carriageway is to be closed eastbound between South Cave and Brough.
The collision was reported by the ambulance service just after 1pm.
Officers on the scene assisting with traffic diversions and undertaking enquiries.
Motorists are advised to avoid the area and seek alternative routes where possible.
Any witnesses to the collision are asked to call Humberside Police quoting log 273 of today 29 June 2018